Targeting human liver cancer cells with lactobionic acid-G (4)-PAMAM-FITC sorafenib loaded dendrimers

RM Iacobazzi, L Porcelli, AA Lopedota… - International journal of …, 2017 - Elsevier
… line HepG-2 compared non-expressing HLE cells. Ac-La-G(4)-PAMAM-FITC dendrimer
loaded with sorafenib was stable and showed sustained sorafenib release. As evidenced by the …

Ligand-mediated Targeted Drug Delivery Approaches against Hepatocellular Carcinoma

A Singh, S Mishra, S Sharma, S Ojha… - … Cancer Drug Targets, 2023 - ingentaconnect.com
Sorafenib-loaded lactobionic acid conjugated G(4)PAMAM-FITC dendrimers were
investigated by Iacobazzi and co-workers for the targeting of human liver cancer cells. …

Exploiting the bioengineering versatility of lactobionic acid in targeted nanosystems and biomaterials

S Alonso - Journal of Controlled Release, 2018 - Elsevier
dendrimer-based systems targeting liver cancer cells. LBA-… rate of loaded DOX as well as
higher liver cancer cell targeting ability … of promising anti-cancer drugs such as sorafenib [37] or …

Targeted delivery of miR-218 via decorated hyperbranched polyamidoamine for liver cancer regression

AM Elfiky, RH Mohamed, FEZ Abd EL-Hakam… - International Journal of …, 2021 - Elsevier
… high loading efficiency of DNA and enhances the cellular … to the widely used PAMAM
dendrimer (G4) which needs multi-… LA moieties against human liver carcinoma cell line (HepG2). …

Nanotechnology based approach for hepatocellular carcinoma targeting

A Alhalmi, S Beg, K Kohli, M Waris… - … Drug Targets, 2021 - ingentaconnect.com
… the liver tumor cells, therefore, increase selective targeting of … and lactobionic acid (MSN-CS-LA
nanocarriers) to target … have shown that sorafenib loaded with dendrimer exhibits superi…

Surface functionalized dendrimers as controlled-release delivery nanosystems for tumor targeting

M Ghaffari, G Dehghan, F Abedi-Gaballu… - European Journal of …, 2018 - Elsevier
… in cancer treatment, iii) surface functionalization of dendrimerloaded dendrimer by
accumulation of gemcitabine in tumorSorafenib encapsulated Ac-La-G (4.0)-PAMAM-FITC

Multifunctional nanoplatform based on star-shaped copolymer for liver cancer targeting therapy

X Gong, Y Zheng, G He, K Chen, X Zeng, Z Chen - Drug Delivery, 2019 - Taylor & Francis
Lactobionic acid (LA), which is composed of one molecule of … ), allowing the targeted delivery
of drugs to liver cancer cells. … F-loaded NPs, human hepatocellular carcinoma cells, HepG2…

Expatiating the pivotal role of Dendrimers as emerging nanocarrier for management of Liver Disorders

N Sharma, I Zahoor, S Singh, T Behl… - Journal of Integrated …, 2023 - pubs.thesciencein.org
… Patent literature status related to application of dendrimers in liver disorders … Targeting
human liver cancer cells with lactobionic acid-G (4)-PAMAM-FITC sorafenib loaded dendrimers. Int…

Biotin functionalized PEGylated poly (amidoamine) dendrimer conjugate for active targeting of paclitaxel in cancer

SVK Rompicharla, P Kumari, H Bhatt, B Ghosh… - International journal of …, 2019 - Elsevier
… ) dendrimers of generation 4 (G4) to deliver paclitaxel (PTX), a poorly soluble anti-cancer
agent precisely to cancer cells … of PTX to cancer cells than non-targeted dendrimer or free drug. …

Preparation and evaluation of folate-decorated human serum albumin nanoparticles for the targeted delivery of sorafenib to enhance antihepatocarcinoma efficacy

W Gao, X Jia, J Wu, Y Song, J Yin, M Zhang… - Journal of Drug Delivery …, 2019 - Elsevier
… -human serum albumin-sorafenib nanoparticles (FA-HSA-SRF-NPs) to improve the active-targeting
to liver tumor cellssorafenib-loaded human serum albumin nanoparticles with active-…